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A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

Gambierol is a marine polycyclic ether toxin belonging to the group of ciguatera toxins. It does not activate voltage-gated sodium channels (VGSCs) but inhibits Kv1 potassium channels by an unknown mechanism. While testing whether Kv2, Kv3, and Kv4 channels also serve as targets, we found that Kv3.1...

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Detalhes bibliográficos
Main Authors: Kopljar, Ivan, Labro, Alain J., Cuypers, Eva, Johnson, Henry W. B., Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688436/
https://ncbi.nlm.nih.gov/pubmed/19482941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812471106
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