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Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels

Marine ladder-shaped polyether toxins are implicated in neurological symptoms of fish-borne food poisonings. The toxin gambierol, produced by the marine dinoflagellate Gambierdiscus toxicus, belongs to the group of ladder-shaped polyether toxins and inhibits Kv3.1 channels with nanomolar affinity th...

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Détails bibliographiques
Publié dans:Neuropharmacology
Auteurs principaux: Kopljar, Ivan, Grottesi, Alessandro, de Block, Tessa, Rainier, Jon D., Tytgat, Jan, Labro, Alain J., Snyders, Dirk J.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7134334/
https://ncbi.nlm.nih.gov/pubmed/26956727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.03.010
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