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Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels
Marine ladder-shaped polyether toxins are implicated in neurological symptoms of fish-borne food poisonings. The toxin gambierol, produced by the marine dinoflagellate Gambierdiscus toxicus, belongs to the group of ladder-shaped polyether toxins and inhibits Kv3.1 channels with nanomolar affinity th...
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| Publicado no: | Neuropharmacology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7134334/ https://ncbi.nlm.nih.gov/pubmed/26956727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.03.010 |
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