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Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening

Alkanols are small aliphatic compounds that inhibit voltage-gated K(+) (K(v)) channels through a yet unresolved gating mechanism. K(v) channels detect changes in the membrane potential with their voltage-sensing domains (VSDs) that reorient and generate a transient gating current. Both 1-Butanol (1-...

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Pubblicato in:Sci Rep
Autori principali: Martínez-Morales, Evelyn, Kopljar, Ivan, Snyders, Dirk J., Labro, Alain J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663795/
https://ncbi.nlm.nih.gov/pubmed/26616025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17402
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