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Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K(+) and Na(+) Channels

In the Na(v) channel family the lipophilic drugs/toxins binding sites and the presence of fenestrations in the channel pore wall are well defined and categorized. No such classification exists in the much larger K(v) channel family, although certain lipophilic compounds seem to deviate from binding...

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Publicado en:Front Pharmacol
Autores principales: Van Theemsche, Kenny M., Van de Sande, Dieter V., Snyders, Dirk J., Labro, Alain J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243439/
https://ncbi.nlm.nih.gov/pubmed/32499709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00735
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