Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore

Podobne zapisy

• A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol
  od: Kopljar, Ivan, i wsp.
  Wydane: (2009)
• The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state
  od: Kopljar, Ivan, i wsp.
  Wydane: (2013)
• Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels
  od: Kopljar, Ivan, i wsp.
  Wydane: (2016)
• Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening
  od: Martínez-Morales, Evelyn, i wsp.
  Wydane: (2015)
• Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels
  od: Cuypers, Eva, i wsp.
  Wydane: (2008)