Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increa...

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Udgivet i:Cancer Cell
Main Authors: Cheung, Eric C., DeNicola, Gina M., Nixon, Colin, Blyth, Karen, Labuschagne, Christiaan F., Tuveson, David A., Vousden, Karen H.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008247/
https://ncbi.nlm.nih.gov/pubmed/31983610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.12.012
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