Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy. However, how the ROS response is determined is not clear. We exa...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Cheung, Eric C., Lee, Pearl, Ceteci, Fatih, Nixon, Colin, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701978/
https://ncbi.nlm.nih.gov/pubmed/26679840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.271130.115
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