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Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increa...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008247/ https://ncbi.nlm.nih.gov/pubmed/31983610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.12.012 |
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