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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS). Here, we show that under hypox...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528527/ https://ncbi.nlm.nih.gov/pubmed/23185017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206530109 |
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