Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1

Muscle function is regulated by Ca(2+), which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca(2+) delivery to the mitochondrial matrix via the mitochondrial Ca(2+) uniporter, the pore of which is formed...

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Vydáno v:Cell Rep
Hlavní autoři: Debattisti, Valentina, Horn, Adam, Singh, Raghavendra, Seifert, Erin L., Hogarth, Marshall W., Mazala, Davi A., Huang, Kai Ting, Horvath, Rita, Jaiswal, Jyoti K., Hajnóczky, György
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007691/
https://ncbi.nlm.nih.gov/pubmed/31665639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.063
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