MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration

Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to post...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Antony, Anil Noronha, Paillard, Melanie, Moffat, Cynthia, Juskeviciute, Egle, Correnti, Jason, Bolon, Brad, Rubin, Emanuel, Csordás, György, Seifert, Erin L., Hoek, Jan B., Hajnóczky, György
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786880/
https://ncbi.nlm.nih.gov/pubmed/26956930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10955
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