MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2+) uniporter

Mitochondrial Ca(2+) uptake via the uniporter is central to cell metabolism, signaling and survival. Recent studies identified MCU as the uniporter’s likely pore and MICU1, an EF-hand protein, as its critical regulator. How this complex decodes dynamic cytoplasmic [Ca(2+)] ([Ca(2+)](c)) signals, to...

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Main Authors: Csordás, György, Golenár, Tünde, Seifert, Erin L., Kamer, Kimberli J., Sancak, Yasemin, Perocchi, Fabiana, Moffat, Cynthia, Weaver, David, Perez, Sergio de la Fuente, Bogorad, Roman, Koteliansky, Victor, Adijanto, Jeffrey, Mootha, Vamsi K., Hajnóczky, György
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722067/
https://ncbi.nlm.nih.gov/pubmed/23747253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.020
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