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MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca(2+) and Mn(2+)
The mitochondrial uniporter is a Ca(2+)-activated Ca(2+) channel complex that displays exceptionally high conductance and selectivity. Here, we report cellular metal toxicity screens highlighting the uniporter’s role in Mn(2+) toxicity. Cells lacking the pore-forming uniporter subunit, MCU, are more...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6112746/ https://ncbi.nlm.nih.gov/pubmed/30082385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807811115 |
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