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MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca(2+) and Mn(2+)

The mitochondrial uniporter is a Ca(2+)-activated Ca(2+) channel complex that displays exceptionally high conductance and selectivity. Here, we report cellular metal toxicity screens highlighting the uniporter’s role in Mn(2+) toxicity. Cells lacking the pore-forming uniporter subunit, MCU, are more...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kamer, Kimberli J., Sancak, Yasemin, Fomina, Yevgenia, Meisel, Joshua D., Chaudhuri, Dipayan, Grabarek, Zenon, Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112746/
https://ncbi.nlm.nih.gov/pubmed/30082385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807811115
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