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High‐affinity cooperative Ca(2+) binding by MICU1–MICU2 serves as an on–off switch for the uniporter

The mitochondrial calcium uniporter is a Ca(2+)‐activated Ca(2+) channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca(2+) signals. It is regulated by two paralogous EF‐hand proteins—MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate t...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kamer, Kimberli J, Grabarek, Zenon, Mootha, Vamsi K
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538426/
https://ncbi.nlm.nih.gov/pubmed/28615291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643748
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