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High‐affinity cooperative Ca(2+) binding by MICU1–MICU2 serves as an on–off switch for the uniporter
The mitochondrial calcium uniporter is a Ca(2+)‐activated Ca(2+) channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca(2+) signals. It is regulated by two paralogous EF‐hand proteins—MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate t...
में बचाया:
| में प्रकाशित: | EMBO Rep |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
John Wiley and Sons Inc.
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538426/ https://ncbi.nlm.nih.gov/pubmed/28615291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643748 |
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