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High‐affinity cooperative Ca(2+) binding by MICU1–MICU2 serves as an on–off switch for the uniporter
The mitochondrial calcium uniporter is a Ca(2+)‐activated Ca(2+) channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca(2+) signals. It is regulated by two paralogous EF‐hand proteins—MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate t...
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| Pubblicato in: | EMBO Rep |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538426/ https://ncbi.nlm.nih.gov/pubmed/28615291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643748 |
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