Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca(2+) Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

Mitochondrial Ca(2+) uptake through the Ca(2+) uniporter supports cell functions, including oxidative metabolism, while meeting tissue-specific calcium signaling patterns and energy needs. The molecular mechanisms underlying tissue-specific control of the uniporter are unknown. Here, we investigated...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Paillard, Melanie, Csordás, György, Szanda, Gergö, Golenár, Tünde, Debattisti, Valentina, Bartok, Adam, Wang, Nadan, Moffat, Cynthia, Seifert, Erin L., Spät, András, Hajnóczky, György
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760244/
https://ncbi.nlm.nih.gov/pubmed/28273446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.032
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