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MICU1 interacts with the D-ring of the MCU pore to control its Ca(2+) flux and sensitivity to Ru360
Proper control of the mitochondrial Ca(2+) uniporter’s pore (MCU) is required to allow Ca(2+) dependent activation of oxidative metabolism and to avoid mitochondrial Ca(2+) overload and cell death. The MCU’s gatekeeping and cooperative activation is mediated by the Ca(2+) sensing MICU1 protein, whic...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6251499/ https://ncbi.nlm.nih.gov/pubmed/30454562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.09.008 |
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