MICU1 and MICU2 Finely Tune the Mitochondrial Ca(2+) Uniporter by Exerting Opposite Effects on MCU Activity

Mitochondrial calcium accumulation was recently shown to depend on a complex composed of an inner-membrane channel (MCU and MCUb) and regulatory subunits (MICU1, MCUR1, and EMRE). A fundamental property of MCU is low activity at resting cytosolic Ca(2+) concentrations, preventing deleterious Ca(2+)...

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Hoofdauteurs: Patron, Maria, Checchetto, Vanessa, Raffaello, Anna, Teardo, Enrico, Vecellio Reane, Denis, Mantoan, Maura, Granatiero, Veronica, Szabò, Ildikò, De Stefani, Diego, Rizzuto, Rosario
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988891/
https://ncbi.nlm.nih.gov/pubmed/24560927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.013
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