TGF-β–driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model

Duchenne muscular dystrophy (DMD) is a chronic muscle disease characterized by poor myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic basis, severity of these deficits varies among patients. One source of these variations is the genetic modifier that leads to i...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mázala, Davi A.G., Novak, James S., Hogarth, Marshall W., Nearing, Marie, Adusumalli, Prabhat, Tully, Christopher B., Habib, Nayab F., Gordish-Dressman, Heather, Chen, Yi-Wen, Jaiswal, Jyoti K., Partridge, Terence A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213798/
https://ncbi.nlm.nih.gov/pubmed/32213706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135703
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