TGF-β–driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model

Duchenne muscular dystrophy (DMD) is a chronic muscle disease characterized by poor myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic basis, severity of these deficits varies among patients. One source of these variations is the genetic modifier that leads to i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Mázala, Davi A.G., Novak, James S., Hogarth, Marshall W., Nearing, Marie, Adusumalli, Prabhat, Tully, Christopher B., Habib, Nayab F., Gordish-Dressman, Heather, Chen, Yi-Wen, Jaiswal, Jyoti K., Partridge, Terence A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213798/
https://ncbi.nlm.nih.gov/pubmed/32213706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135703
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