TGF-β–driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model

Duchenne muscular dystrophy (DMD) is a chronic muscle disease characterized by poor myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic basis, severity of these deficits varies among patients. One source of these variations is the genetic modifier that leads to i...

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Pubblicato in:JCI Insight
Autori principali: Mázala, Davi A.G., Novak, James S., Hogarth, Marshall W., Nearing, Marie, Adusumalli, Prabhat, Tully, Christopher B., Habib, Nayab F., Gordish-Dressman, Heather, Chen, Yi-Wen, Jaiswal, Jyoti K., Partridge, Terence A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213798/
https://ncbi.nlm.nih.gov/pubmed/32213706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135703
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