MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstr...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Wild, Klemens, Aleksić, Milan, Lapouge, Karine, Juaire, Keven D., Flemming, Dirk, Pfeffer, Stefan, Sinning, Irmgard
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005732/
https://ncbi.nlm.nih.gov/pubmed/32034140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14603-7
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