MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstr...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Wild, Klemens, Aleksić, Milan, Lapouge, Karine, Juaire, Keven D., Flemming, Dirk, Pfeffer, Stefan, Sinning, Irmgard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005732/
https://ncbi.nlm.nih.gov/pubmed/32034140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14603-7
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