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MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Wild, Klemens, Aleksić, Milan, Lapouge, Karine, Juaire, Keven D., Flemming, Dirk, Pfeffer, Stefan, Sinning, Irmgard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005732/
https://ncbi.nlm.nih.gov/pubmed/32034140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14603-7
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