Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site

During 60S biogenesis, mature 5S RNP consisting of 5S RNA, RpL5 and RpL11, assembles into a pre-60S particle, where docking relies on RpL11 interacting with helix 84 (H84) of the 25S RNA. How 5S RNP is assembled for recruitment into the pre-60S is not known. Here we report the crystal structure of a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Calviño, Fabiola R., Kharde, Satyavati, Ori, Alessandro, Hendricks, Astrid, Wild, Klemens, Kressler, Dieter, Bange, Gert, Hurt, Ed, Beck, Martin, Sinning, Irmgard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396368/
https://ncbi.nlm.nih.gov/pubmed/25849277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7510
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