CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises their...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Dong, Yifei, Arif, Arif A., Guo, Jian, Ha, Zongyi, Lee-Sayer, Sally S. M., Poon, Grace F. T., Dosanjh, Manisha, Roskelley, Calvin D., Huan, Tao, Johnson, Pauline
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002364/
https://ncbi.nlm.nih.gov/pubmed/32082314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00029
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