CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises their...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Dong, Yifei, Arif, Arif A., Guo, Jian, Ha, Zongyi, Lee-Sayer, Sally S. M., Poon, Grace F. T., Dosanjh, Manisha, Roskelley, Calvin D., Huan, Tao, Johnson, Pauline
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002364/
https://ncbi.nlm.nih.gov/pubmed/32082314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00029
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