CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises their...

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Vydáno v:Front Immunol
Hlavní autoři: Dong, Yifei, Arif, Arif A., Guo, Jian, Ha, Zongyi, Lee-Sayer, Sally S. M., Poon, Grace F. T., Dosanjh, Manisha, Roskelley, Calvin D., Huan, Tao, Johnson, Pauline
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002364/
https://ncbi.nlm.nih.gov/pubmed/32082314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00029
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