CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises their...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Dong, Yifei, Arif, Arif A., Guo, Jian, Ha, Zongyi, Lee-Sayer, Sally S. M., Poon, Grace F. T., Dosanjh, Manisha, Roskelley, Calvin D., Huan, Tao, Johnson, Pauline
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002364/
https://ncbi.nlm.nih.gov/pubmed/32082314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00029
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