Type II but not type I interferon signaling is indispensable for TLR7-promoted development of autoreactive B cells and systemic autoimmunity

TLR7 is associated with development of systemic lupus erythematosus (SLE), but the underlying mechanisms are incompletely understood. Although TLRs are known to activate type I interferon (T1IFN) signaling, the role of T1IFN and IFNγ signaling in differential regulation of TLR7-mediated antibody-for...

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Bibliographic Details
Published in:J Immunol
Main Authors: Chodisetti, Sathi Babu, Fike, Adam J., Domeier, Phillip P., Singh, Harinder, Choi, Nicholas M., Corradetti, Chelsea, Kawasawa, Yuka Imamura, Cooper, Timothy K., Caricchio, Roberto, Rahman, Ziaur S.M.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002260/
https://ncbi.nlm.nih.gov/pubmed/31900342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901175
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