B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

Type 1 interferon (T1IFN) signaling promotes inflammation and lupus pathology, but its role in autoreactive B cell development in the antibody-forming cell (AFC) and germinal center (GC) pathways is unclear. Using a lupus model that allows for focused study of the AFC and GC responses, we show that...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Domeier, Phillip P., Chodisetti, Sathi Babu, Schell, Stephanie L., Kawasawa, Yuka Imamura, Fasnacht, Melinda J., Soni, Chetna, Rahman, Ziaur S.M.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089613/
https://ncbi.nlm.nih.gov/pubmed/29996101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.046
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