IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to promote autoimmunity. However, the mechanisms that regulate Spt-GC development are not clear. In this study, we report tha...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Exp Med
Hlavní autoři: Domeier, Phillip P., Chodisetti, Sathi Babu, Soni, Chetna, Schell, Stephanie L., Elias, Melinda J., Wong, Eric B., Cooper, Timothy K., Kitamura, Daisuke, Rahman, Ziaur S.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854731/
https://ncbi.nlm.nih.gov/pubmed/27069112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151722
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky