IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to promote autoimmunity. However, the mechanisms that regulate Spt-GC development are not clear. In this study, we report tha...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Domeier, Phillip P., Chodisetti, Sathi Babu, Soni, Chetna, Schell, Stephanie L., Elias, Melinda J., Wong, Eric B., Cooper, Timothy K., Kitamura, Daisuke, Rahman, Ziaur S.M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854731/
https://ncbi.nlm.nih.gov/pubmed/27069112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151722
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