Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity

The inhibitory IgG Fc receptor (FcγRIIB) deficiency and 129 strain-derived signaling lymphocyte activation molecules (129-SLAMs) are proposed to contribute to the lupus phenotype in FcγRIIB-deficient mice generated using 129 ES cells and backcrossed to C57BL/6 mice (B6.129.RIIBKO). In this study, we...

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Veröffentlicht in:J Autoimmun
Hauptverfasser: Soni, Chetna, Domeier, Phillip P., Wong, Eric B., Shwetank, Khan, Tahsin N., Elias, Melinda J., Schell, Stephanie L., Lukacher, Aron E., Cooper, Timothy K., Rahman, Ziaur S.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564365/
https://ncbi.nlm.nih.gov/pubmed/26162758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.06.011
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