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Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4(+) helper T cell responses leading to autoantibody production
Mer (MerTK) is a member of the Tyro-3/Axl/Mer (TAM) subfamily of receptor tyrosine kinases and its expression on phagocytes facilitates their clearance of apoptotic cells (ACs). Mer expression in germinal centers (GCs) occurs predominantly on tingible body macrophages (TBMϕs). B and T cells do not e...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563756/ https://ncbi.nlm.nih.gov/pubmed/23319738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200824 |
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