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Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses
Germinal centers (GC) are specialized microenvironments that generate high-affinity antibody-forming (AFCs) and memory B cells. Many B cells undergo apoptosis during B-cell clonal selection in GC. Although the factors that regulate the AFC and GC responses are not precisely understood, it is widely...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563244/ https://ncbi.nlm.nih.gov/pubmed/20952679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001187 |
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