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B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers
Spontaneous germinal center (Spt-GC) B cells and follicular helper T cells (Tfh) generate high affinity autoantibodies involved in the development of systemic lupus erythematosus (SLE). Toll like receptors (TLRs) play a pivotal role in SLE pathogenesis. While previous studies have focused on the B c...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201954/ https://ncbi.nlm.nih.gov/pubmed/25252960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401720 |
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