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Type II but not type I interferon signaling is indispensable for TLR7-promoted development of autoreactive B cells and systemic autoimmunity
TLR7 is associated with development of systemic lupus erythematosus (SLE), but the underlying mechanisms are incompletely understood. Although TLRs are known to activate type I interferon (T1IFN) signaling, the role of T1IFN and IFNγ signaling in differential regulation of TLR7-mediated antibody-for...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7002260/ https://ncbi.nlm.nih.gov/pubmed/31900342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901175 |
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