Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells

Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (a...

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Pubblicato in:J Virol
Autori principali: Russier, Marion, Yang, Guohua, Briard, Benoit, Meliopoulos, Victoria, Cherry, Sean, Kanneganti, Thirumala-Devi, Schultz-Cherry, Stacey, Vogel, Peter, Russell, Charles J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000976/
https://ncbi.nlm.nih.gov/pubmed/31694942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01423-19
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