Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells

Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (a...

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Publicat a:J Virol
Autors principals: Russier, Marion, Yang, Guohua, Briard, Benoit, Meliopoulos, Victoria, Cherry, Sean, Kanneganti, Thirumala-Devi, Schultz-Cherry, Stacey, Vogel, Peter, Russell, Charles J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000976/
https://ncbi.nlm.nih.gov/pubmed/31694942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01423-19
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