Type I Interferon Response Limits Astrovirus Replication and Protects against Increased Barrier Permeability In Vitro and In Vivo

Little is known about intrinsic epithelial cell responses against astrovirus infection. Here we show that human astrovirus type 1 (HAstV-1) infection induces type I interferon (beta interferon [IFN-β]) production in differentiated Caco2 cells, which not only inhibits viral replication by blocking po...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Marvin, Shauna A., Huerta, C. Theodore, Sharp, Bridgett, Freiden, Pamela, Cline, Troy D., Schultz-Cherry, Stacey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733991/
https://ncbi.nlm.nih.gov/pubmed/26656701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02367-15
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