Type I Interferon Response Limits Astrovirus Replication and Protects against Increased Barrier Permeability In Vitro and In Vivo

Little is known about intrinsic epithelial cell responses against astrovirus infection. Here we show that human astrovirus type 1 (HAstV-1) infection induces type I interferon (beta interferon [IFN-β]) production in differentiated Caco2 cells, which not only inhibits viral replication by blocking po...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Marvin, Shauna A., Huerta, C. Theodore, Sharp, Bridgett, Freiden, Pamela, Cline, Troy D., Schultz-Cherry, Stacey
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733991/
https://ncbi.nlm.nih.gov/pubmed/26656701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02367-15
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