Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells

Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (a...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Virol
Main Authors: Russier, Marion, Yang, Guohua, Briard, Benoit, Meliopoulos, Victoria, Cherry, Sean, Kanneganti, Thirumala-Devi, Schultz-Cherry, Stacey, Vogel, Peter, Russell, Charles J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2020
נושאים:
Pathogenesis and Immunity
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000976/
https://ncbi.nlm.nih.gov/pubmed/31694942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01423-19
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