Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells

Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Russier, Marion, Yang, Guohua, Briard, Benoit, Meliopoulos, Victoria, Cherry, Sean, Kanneganti, Thirumala-Devi, Schultz-Cherry, Stacey, Vogel, Peter, Russell, Charles J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000976/
https://ncbi.nlm.nih.gov/pubmed/31694942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01423-19
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker