Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of...

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Detaylı Bibliyografya
Yayımlandı:Comput Struct Biotechnol J
Asıl Yazarlar: Vedithi, Sundeep Chaitanya, Rodrigues, Carlos H.M., Portelli, Stephanie, Skwark, Marcin J., Das, Madhusmita, Ascher, David B., Blundell, Tom L., Malhotra, Sony
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Research Network of Computational and Structural Biotechnology 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000446/
https://ncbi.nlm.nih.gov/pubmed/32042379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.01.002
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