HARP: a database of structural impacts of systematic missense mutations in drug targets of Mycobacterium leprae

Computational Saturation Mutagenesis is an in-silico approach that employs systematic mutagenesis of each amino acid residue in the protein to all other amino acid types, and predicts changes in thermodynamic stability and affinity to the other subunits/protein counterparts, ligands and nucleic acid...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Vedithi, Sundeep Chaitanya, Malhotra, Sony, Skwark, Marcin J., Munir, Asma, Acebrón-García-De-Eulate, Marta, Waman, Vaishali P, Alsulami, Ali, Ascher, David B, Blundell, Tom L
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7711215/
https://ncbi.nlm.nih.gov/pubmed/33304465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.013
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