Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Vedithi, Sundeep Chaitanya, Rodrigues, Carlos H.M., Portelli, Stephanie, Skwark, Marcin J., Das, Madhusmita, Ascher, David B., Blundell, Tom L., Malhotra, Sony
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000446/
https://ncbi.nlm.nih.gov/pubmed/32042379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.01.002
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