Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae

Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Comput Struct Biotechnol J
Prif Awduron: Vedithi, Sundeep Chaitanya, Rodrigues, Carlos H.M., Portelli, Stephanie, Skwark, Marcin J., Das, Madhusmita, Ascher, David B., Blundell, Tom L., Malhotra, Sony
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Research Network of Computational and Structural Biotechnology 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000446/
https://ncbi.nlm.nih.gov/pubmed/32042379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.01.002
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