Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present study, we identified mutations corresponding to rifampin resistance in r...

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Pubblicato in:Sci Rep
Autori principali: Vedithi, Sundeep Chaitanya, Malhotra, Sony, Das, Madhusmita, Daniel, Sheela, Kishore, Nanda, George, Anuja, Arumugam, Shantha, Rajan, Lakshmi, Ebenezer, Mannam, Ascher, David B., Arnold, Eddy, Blundell, Tom L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864748/
https://ncbi.nlm.nih.gov/pubmed/29567948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23423-1
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