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Mitochondrial mass governs the extent of human T cell senescence

The susceptibility of human CD4(+) and CD8(+) T cells to senesce differs, with CD8(+) T cells acquiring an immunosenescent phenotype faster than the CD4(+) T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Callender, Lauren A., Carroll, Elizabeth C., Bober, Emilia A., Akbar, Arne N., Solito, Egle, Henson, Sian M.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996952/
https://ncbi.nlm.nih.gov/pubmed/31788930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13067
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