GATA3 induces mitochondrial biogenesis in primary human CD4(+) T cells during DNA damage

GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4(+) T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, proliferation and maintenance in other T cell and non-T cell lineages. Here we show a mechanism utilised by...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Callender, Lauren A., Schroth, Johannes, Carroll, Elizabeth C., Garrod-Ketchley, Conor, Romano, Lisa E. L., Hendy, Eleanor, Kelly, Audrey, Lavender, Paul, Akbar, Arne N., Chapple, J. Paul, Henson, Sian M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184923/
https://ncbi.nlm.nih.gov/pubmed/34099719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23715-7
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