p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells

T cell senescence is thought to contribute to immune function decline, but the pathways that mediate senescence in these cells are not clear. Here, we evaluated T cell populations from healthy volunteers and determined that human CD8(+) effector memory T cells that reexpress the naive T cell marker...

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Bibliographische Detailangaben
Hauptverfasser: Henson, Sian M., Lanna, Alessio, Riddell, Natalie E., Franzese, Ornella, Macaulay, Richard, Griffiths, Stephen J., Puleston, Daniel J., Watson, Alexander Scarth, Simon, Anna Katharina, Tooze, Sharon A., Akbar, Arne N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151208/
https://ncbi.nlm.nih.gov/pubmed/25083993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75051
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