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IFN-α Inhibits Telomerase in Human CD8(+) T Cells by Both hTERT Downregulation and Induction of p38 MAPkinase Signalling
The cytokine IFN-α is secreted during viral infections and has been shown to inhibit telomerase activity and accelerate T cell differentiation in vivo. However the mechanism for this inhibition is not clear. In this study we show that IFN-α inhibits both the transcription and translation of hTERT, t...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836248/ https://ncbi.nlm.nih.gov/pubmed/23997212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301409 |
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