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AMPK-TAB1 activated p38 drives human T cell senescence
In T lymphocytes, p38 MAP kinase (MAPK) regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative T cell receptor (TCR) activation pathway. Here we show that senescent human T cells lack the canonical and alternative pathways of p38 activation, but spontaneously...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4190666/ https://ncbi.nlm.nih.gov/pubmed/25151490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2981 |
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