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Mitochondrial mass governs the extent of human T cell senescence
The susceptibility of human CD4(+) and CD8(+) T cells to senesce differs, with CD8(+) T cells acquiring an immunosenescent phenotype faster than the CD4(+) T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD...
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| Veröffentlicht in: | Aging Cell |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996952/ https://ncbi.nlm.nih.gov/pubmed/31788930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13067 |
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